"Malaysia Airlines confirms it received notification from Ukrainian ATC that it had lost contact with flight MH17 at 1415 (GMT) at 30km from Tamak waypoint, approximately 50km from the Russia-Ukraine border.
Flight MH17 operated on a Boeing 777 departed Amsterdam at 12.15pm (Amsterdam local time) and was estimated to arrive at Kuala Lumpur International Airport at 6.10 am (Malaysia local time) the next day.
The flight was carrying 280 passengers and 15 crew onboard."
An Associated Press journalist counted at least 22 bodies at the wreckage site 25 miles from the Russian border.
According to the Associated Press, The Boeing 777-200ER plane appeared to have broken up before impact and the burning wreckage — which included body parts and the belongings of passengers — was scattered over a wide area.
Ukrainian President Petro Poroshenko called the downing an act of terrorism and called for an international investigation into the crash. He insisted that his forces did not shoot down the plane.
President Barack Obama called the crash a "terrible tragedy."
The village of Grabovo is currently under the control of pro-Russia separatists and the area has seen severe fighting between the two sides in recent days.
The Ukrainian government and the pro-Russia separatists fighting in the region denied any responsibility for downing the plane.
According to CNN military analyst Rick Francona, a retired Air Force colonel, a surface-to-air missile is most likely the case.
The Buk missile system operated by Russian and Ukrainian forces is a likely candidate.
The Kremlin released a statement late Thursday indicating that President Obama and Russian President Vladimir Putin had spoken of the crash:
"The Russian leader informed the U.S. president of the report from air traffic controllers that the Malaysian plane had crashed on Ukrainian territory, which had arrived immediately before the phone call."
No further details on what they discussed were released.
Aviation authorities in several countries, including the FAA in the United States, had issued warnings not to fly over parts of Ukraine prior to Thursday's crash. Within hours, several airlines, including Lufthansa and KLM, released statements Thursday saying they were avoiding parts of Ukrainian airspace.
Wasn't the plane that went missing over the Indian Ocean a Malaysia Airlines flight?
Yes. This is the second Boeing 777 jetliner loss in 131 days for Malaysia Airlines. The disappearance of Flight 370 is no closer to being solved, though searches are slated to resume in the South Indian Ocean in August.
Has a domestic flight been allegedly shot down like this before?
On April 20, 1978, Korean Airlines Flight 902 diverted from its planned course on a flight from Paris to Seoul and strayed over the Soviet Union. After being fired upon by an interceptor aircraft, the crew made a forced landing at night on the surface of a frozen lake. Two of the 97 passengers were killed by the hostile fire.
On September 1, 1983, Korean Airlines Flight 007, a domestic Korean Airlines flight from New York City to Seoul, was shot down in Russian airspace over the Sea of Japan. Soviet Union fighter pilots fired a heat-seeking missile that resulted in the loss of 269 passenger and crew lives. This escalated tensions between the U.S. and Russia during the Cold War.
On July 3, 1988, Iran Air Flight 655 was shot down by a surface to air missile from the American naval vessel U.S.S. Vincennes. All on board (16 crew and 274 passengers) were killed.