Zusi slipped behind the defense and ran onto a long well-played ball from Jimmy Medrandabefore chipping it over a sliding defender and goalkeeper Stefan Frei in the 78th minute.
Ilie Sanchez converted from the spot to give Sporting (4-1-1) a 1-0 lead in the 34th minute after Johnny Russell drew a foul in the area against Nouhou Tolo.
Will Bruin scored Seattle’s first goal of the season, making it 1-1 in the third minute of first-half stoppage time. Nicolas Lodeiro’s long throw-in was headed by Chad Marshall on the left side of the box to Bruin, who tapped it in with the outside of his foot from point-blank range. Christian Roldan gave the Sounders (0-3-1) a 2-1 lead in the 73rd with a low one-timer from the top of the box off a feed from Bruin.
Frei made a diving stop of a slow roller by Roger Espinosa in the first minute of injury time.
Seattle snapped a four-game road scoreless streak, the longest in club history.