Police tell 41 Action News that Independence Police were chasing a stolen blue Jeep Patriot with four suspects inside at a high rate of speed.
Police momentarily lost sight of the Jeep and when they caught back up, they discovered the Jeep had crashed into a silver Dodge Avenger that was not involved in the chase.
Four people were in the silver passenger car. A man and woman in the silver car died in the crash. One suspect also died in the Jeep.
Five others - two people in the car and three suspects in the Jeep - were injured. Four were taken to the hospital in critical condition and the driver of the Jeep was in serious but not life-threatening condition.
The chase started at E. 23rd Street and Maywood, three miles east of the crash.
The intersection is likely to remain closed while police investigate the scene.
Stay with 41 Action News for more on this developing story.