KANSAS CITY, Mo. — Running back Clyde Edwards-Helaire left the game on the Kansas City Chiefs’ second drive of the third quarter.
After catching a screen pass and powering his way 11 yards to a first down, Edwards-Helaire was slow to get up.
It appeared to be a left leg injury after he got folded over while being tackled.
The Chiefs announced he was out with a knee injury.
Edwards-Helaire, who had back-to-back 100-yard games the last two weeks, was struggling to get untracked before the injury.
He only had 13 yards on seven carries.
Entering the game, Edwards-Helaire led the Chiefs with 291 yards rushing and ranked second with 341 total yards from scrimmage.
Darrel Williams and Jerick McKinnon are Edwards-Helaire's backups at the tailback spot.
Edwards-Helaire, a first-round pick in the 2020 NFL Draft, missed four games last season, including the AFC Divisional win against Cleveland.
He suffered a groin injury in a Week 14 win at New Orleans and missed the next three games.